liposomes

什么是微脂囊包裹技术

脂质体（Liposomes）是由卵磷脂和神经酰胺等制得的脂质体（空心），具有的双分子层结构与皮肤细胞膜结构相同，对皮肤有优良的保湿作用，尤其是包敷了保湿物质如透明质酸、聚葡糖苷等的脂质体是更优秀的保湿性物质。

脂质体（liposome）是一种人工膜。在水中磷脂分子亲水头部插入水中，脂质体疏水尾部伸向空气，搅动后形成双层脂分子的球形脂质体，直径25~1000nm不等。

脂质体可用于转基因，或制备的药物，利用脂质体可以和细胞膜融合的特点，将药物送入细胞内部 生物学定义：当两性分子如磷脂和鞘脂分散于水相时，分子的疏水尾部倾向于聚集在一起，避开水相，而亲水头部暴露在水相，形成具有双分子层结构的的封闭囊泡，称为脂质体。

药剂学定义 脂质体（liposome）: 系指将药物包封于类脂质双分子层内而形成的微型泡囊体。

脂质体的分类：

1、脂质体按照所包含类脂质双分子层的层数不同，分为单室脂质体和多室脂质体。

小单室脂质体（SUV）：粒径约0.02～0.08μm；大单室脂质体（LUV）为单层大泡囊，粒径在0.1～lμm。

多层双分子层的泡囊称为多室脂质体（MIV），粒径在1～5μm之间。

2、按照结构分：单室脂质体，多室脂质体，多囊脂质体。

3、按照电荷分：中性脂质体，负电荷脂质体，正电荷脂质体。

4、按照性能分：一般脂质体，特殊功效脂质体。

丽普司肽淘宝旗舰店是真的吗

微脂囊技术是目前化妆品渗透工艺中最顶尖的技术，微脂囊是一种特殊的脂质体包裹着各种活性成分的微粒。这种脂质体能高效渗透到皮肤基底层，比一般护肤品吸收更快效果更佳,运用于基础护肤品中，效力自然比传统护肤品更胜一筹。

微脂囊包裹着水分和养分，其直径革命性地比传统护肤品缩小1000倍（以纳米为计算单位），轻易便可以穿透毛孔和角质层细胞的间隙，进入皮肤深层，这意味着皮肤可以吸收到更多的水分和养分，最大限度地补充真皮营养传递的不足。

而且余下的小部分养分停留于角质层上保护皮肤内部水分的散失，使皮肤真正滋润饱满活力无限，长期涂擦运用了此科技的护肤品，可以更好地延缓皮肤的衰老。

扩展资料：

微脂囊(Liposomes)是近年来才迅速发展的一种生化科技,它是一种媒介与载体,各种不易渗透进入皮肤及毛发的成份,可借助它顺利地进入皮肤深层。

微脂囊是从一些类脂物质（例如黄豆卵磷脂）中所提炼的一种微小且空心的球状物质，小到无法用肉眼、放大镜或一般显微镜来观察，唯有借助电子显微镜才能看到它，而且它的直径不会超过千分之一毫米。直径只有30nm的微脂囊能顺利通过50nm的皮肤角质层，把有效成分送到真皮层和基底层。微脂囊没有固定的结构，是许多小分子聚集而成的聚合体。

微脂囊特性：

1.对皮肤具极佳亲和性。

2.能在短时间内附着于表皮层之上。

3.使皮肤有光泽。

4.对皮肤产生保护作用。

5.可穿过表皮层到达深层皮肤。

6.软化细胞膜，使细胞恢复年轻。

7.可以防止水分过度流失，防止外界物质污染皮肤。

参考资料：

搜狐-美容界的创新技术---微脂囊。

脂质体是固体还是液体？能不能实现液体药物固体化？

是的。丽普司肽淘宝旗舰店是牌官方企业运营授权的官网旗舰店。丽普司肽Lipostides，是Liposomes和Peptide的融合，来源于科技界最高荣誉的国家科技进步奖，完美融合了基因工程生物活性蛋白高表达技术和。

高分悬赏，中文翻译成英语，机器翻译的不要

脂质体时“a milk-like liquid”，类似以液体。你可以通过冷冻干燥，让它成为固体状。

Yang, S.; Liu, W.; Liu, C.; Liu, W.; Tong, G.; Zheng, H.; Zhou, W. Characterization and Bioavailability of Vitamin C Nanoliposomes Prepared by Film Evaporation-Dynamic High Pressure Microfluidization. J. Dispers. Sci. Technol. 2012, 33, 1608–1614.请看这篇文献的【脂质体的制备方法】部分。

三氯化扎用什么溶解清除巨噬细胞

翻译如下：Preparation of coenzyme Q10 precursor liposome 1 emulsion evaporation combined with high-pressure homogenization method。

Precursor liposome (proliposome), also known as the reconstruction of liposome, the precursor form of liposome, usually dry and have good flow properties of the powder, the precursor liposome generally do not have the integrity of the bilayer lipid membrane. But the bilayer lipid membrane fragments or lipid membrane attached to a support agent crystallization, or with the support agent are evenly mixed, application and water hydration can form intact liposomes. It has a series of characteristics of liposome preparations, and can solve the problem of easy hydrolysis, aggregation, hierarchical, the drug leakage and high-temperature sterilization is not stable, laid the basis for the design for the industrial production of liposomes, so at home and abroad has aroused extensive research on [120-121].。

Preparation method is simple, storage stability than liposomes corresponding suspension to improve, will open up new practical significance of enlarging the production and application of liposomes. But the main reason proliposome commercialization process is still relatively slow is。

(1) Proliposomes quality is difficult to control, such as by dilution or rehydration preparation of liposome size distribution is not uniform enough (2)。

The drug entrapment efficiency is not up to the requirements. (3) targeting remains to be improved, this is mainly because in the organism, the size of liposome size determines its in vivo and cell function and the location of the in vivo absorption and distribution. Such as the condition of intravenous injection, liposomes small can reach the liver cells soon; liposome size to maintain a considerable period of time in the blood circulation; larger liposomes can not reach the part receiving the medicine [122-123].。

For all of these reasons, we have decided to adopt emulsion evaporation to prepare coenzyme Q10 precursor liposome with high pressure homogenization method. This method is based on modified emulsion evaporation method: first the formation of O/W emulsion, the organic solvent volatile after decompression, internal medicine crystallization in single phospholipid membrane, because the structure is not stable, and the film side invagination, finally ends into a double membrane structure. The formation of the liposomes modified high pressure homogenization particle size, adding additional agent after freeze drying to obtain proliposome powder dry. This method can not only obtain the precursor liposome nanometer level, in order to improve the targeting and product quality stability, but also can prevent the lipid oxidation, simple operation, easy industrialization production.。

1.1 experimental materials and equipment of RE-52AA type rotary evaporator, Shanghai Qingpu Huxi instrument factory; KQ-250DB NC Ultrasonic cleaner, Gongyi Yuhua Instrument Co., Ltd.; Scientz-10N type vacuum freezing dryer, Ningbo scientz biotechnology Polytron Technologies Inc; NS1001L。

High pressure homogenizer, Italy GEA Niro Soavi; Biofuge 22R type low speed centrifuge, the German company Heraeus。

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